2. Joint Toxic Action Data for the Mixture of Concern and Component Mixtures
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چکیده
No studies were located that examined health effects in humans or animals exposed to threeor fourmembered mixtures of the five components of concern. No PBPK models were found for threeor fourmembered mixtures of these chemicals. The following subsections present evaluations of health effects data and discussions of mechanistic information pertinent to the joint toxic action of each pair of components.
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Toxic Action Data for the Mixture of Concern and Component Mixtures
Simultaneous exposure to a mixture can cause two or more chemicals to compete for enzyme-mediated biotransformation, resulting in an inhibition of at least one of the chemicals. The inhibition is termed ‘competitive’ when the chemicals compete as substrates for the same site on an enzyme. In ‘noncompetitive inhibition’, the inhibitor binds to the enzyme, causing a change in the stereochemical a...
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